What domains are in LPHN3?
Gal Lectin: binding domain that bind exclusively to beta-galactosidase. No metal ions are required for its activity. Regulated developmentally, may be involved in differentiation and tissue construction.
OLF: Olfactory receptor, binds odorants to receptor proteins in the cilia of olfactory receptor cells. Odorant binding may initiate membrane depolarization. Cyclic AMP may be an intracellular messenger for olfactory transduction.
HR: Hormone receptor, that binds to specific hormones and can initiate a signal transduction mechanism.
GAIN: The autoproteolysis-inducing domain, it is an ancient evolutionary fold present in all adhesion GPCRs. This domain is important in self cleavage and overall protein function.
GPS: Another autoproteolysis site, highly conserved region of GPCRs. Works with the GAIN domain in functionality and autoproteolysis.
7-Transmembrane: Integral region of any GPCR. Allows for the protein to integrate itself inside the plasma membrane. Connected are the extracellular and intracellular components.
Latrophilin: The intracellular component of LPHN3.