"This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison."
What are Protein Interaction Networks?
Protein-protein interactions are important for determining how a protein functions. Knowing cross talk between proteins is integral for understanding its biological processes. Interaction networks can also help compartmentalize proteins that have a wide range of functions. Protein interaction networks are usually made from studying model organisms. Yeast two-hybrid screens, coimmunoprecipitation, TAP tag affinity purification, and mass spectrometry can all be used to infer protein interaction networks. The result can then be used to help predict how a specific protein will function within a human (1).
What are the LPHN3 interaction Networks?
Figure 1. LPHN3 protein interaction network in homo sapiens.
Figure 3. LPHN3 protein interaction network in humans.
Figure 2. LPHN3.1 protein interaction network in dano rerio.
Figure 4. LPHN3.1 protein interaction network in zebrafish.
How LPHN3 functions with other proteins is not well categorized. Here I used STRING to show relationships between LPHN3 in humans and in zebrafish. Since we know LPHN3 is localized in the brain and important for synapses, it is no surprise that SHANK (a protein found in post synaptic density) is shared among the two. Teneurins have been discovered to bind to LPHN3, but they did not show up on STRING. LPHN3 has several extracellular ligand binding domains, it is expected that as more research is done on LPHN3 this network will expand tremendously.
References: 1. lrich Stelzl, Uwe Worm, Maciej Lalowski, Christian Haenig, Felix H. Brembeck, Heike Goehler, Martin Stroedicke, Martina Zenkner, Anke Schoenherr, Susanne Koeppen, Jan Timm, Sascha Mintzlaff, Claudia Abraham, Nicole Bock, Silvia Kietzmann, Astrid Goedde, Engin Toksöz, Anja Droege, Sylvia Krobitsch, Bernhard Korn, Walter Birchmeier, Hans Lehrach, Erich E. Wanker, A Human Protein-Protein Interaction Network: A Resource for Annotating the Proteome, Cell, Volume 122, Issue 6, 23 September 2005, Pages 957-968, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2005.08.029.
Images: cover photo: https://www.mdc-berlin.de/16074687/en/news/archive/2008/20080910-erwin_schr_dinger_prize_2008_goes_to_resea/P__PRESS2008_WANKER_SCHROEDINGER_PRIZE_PROTEIN_NETWORK.jpg Figure 1&2: created on string http://string-db.org/